Histopathology

Histopathology

Supporting Vets with Post Mortem Histopathology

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At VPG, we understand that post mortem submissions can be an essential part of veterinary diagnostics, helping to provide answers in difficult cases and contributing to wider clinical understanding. Our Histopathology team is here to support you with a straightforward submission process and accurate interpretation of findings. When to Submit Tissues or Cadavers In some…
Case Studies, Histopathology

CASE STUDY: Pneumocystosis in a Dog

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Clinical history: A 7-year-old, male neutered, Cavalier King Charles Spaniel presented with a four-week history of progressively worsening tachypnoea, developing into dyspnoea. CT imaging under sedation revealed generalised ground glass appearance throughout the lung fields, deemed to be consistent with non-cardiogenic oedema. The dog was treated with trimethoprim-potentiated sulfonamides and oxygen supplementation, but deteriorated and…
Case Studies, Histopathology

Case Study: Feline Herpes Virus-Induced Dermatitis: Clinical and Histological Insights

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A biopsy from an external nose lesion on a 13-year-old domestic longhair male neutered cat was submitted to our laboratory. Histopathology identified a severe ulcerative necrotising dermatitis with numerous intranuclear inclusion bodies. These histological changes, in combination with the anatomical location are consistent with a herpesvirus infection. Feline herpes virus ulcerative dermatitis is a rare…
Case Studies, Histopathology

Case Study: Feline Ventral Abdominal Wall Angiosarcoma

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Clinical history Simba, 9 year old male intact domestic shorthair cat, presented with firm rapidly growing large subcutaneous ulcerated mass on the inguinal area.  The ventral abdominal haired skin containing a portion of the inguinal mass and the inguinal lymph node are submitted for histopathology. Histology The dermis and the subcutis are markedly expanded by…
Histopathology

Histology Tips and Tricks: Sampling of the Hepatobiliary Tree

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General Information Biopsy of the hepatobiliary tree is often required for investigation of hepatobiliary disease. Techniques for biopsy of the hepatobiliary tree include needle biopsy (Tru-cut biopsy), laparoscopic biopsy (cup forceps), surgical biopsy (i.e. wedge or guillotine biopsy), and liver lobectomy. Gall bladder sampling most often involves cholecystectomy, but incisional biopsies may also be taken….
Histopathology

Histopathology: Sampling and shipment tips and tricks

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Corresponding to other laboratory tests, the quality of histopathology reporting is directly related to the quality of the sample received. This document will explain common pitfalls in sampling and shipment of histopathology samples to help you avoid introducing pre-analytical artefacts. Sampling In particular when taking small biopsies, even with careful sampling, crush artefact cannot always…
Case Studies, Histopathology

Cutaneous Sarcomas In Pet Degus

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Introduction Neoplasia is considered uncommon in degus, with previous research indicating a low incidence in this species. A study by Jekl et al. (2011) found that only six out of 300 pet degus examined showed evidence of neoplastic disease. Among the reported cases, fibrosarcomas have been identified as the most prevalent cutaneous neoplasm, as highlighted…
Case Studies, Histopathology

Case of the Month: Hepatocutaneous Syndrome in a Cavalier King Charles Spaniel

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Clinical history Chucky was presented to the primary veterinary care practice with a 1 month history of hyperkeratosis, crusting and erythema of the skin of all four paws. A previous canine biochemical profile conducted at VPG revealed significantly elevated alkaline phosphatase (ALP), alanine transaminase (ALT), glutamate dehydrogenase (GLDH) and bile acids. A small liver was…
Histopathology

Histopathology: Sampling and shipment guidelines

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Corresponding to other laboratory tests, the quality and accuracy of histopathology reporting is directly related to the quality of the sample received. This document will explain common pitfalls in sampling and shipment of histopathology samples to help you avoid introducing pre-analytical artefacts such as crush artefact pictured below. Fixation Always use 10% neutral-buffered formalin (NBF)…
Case Studies, Histopathology

Case of the Month: “Yellow fungus disease” in a bearded dragon (Pogona vitticeps)

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A 1 year old bearded dragon developed chronic crusty lesions over the body, face and tail. Skin biopsies were taken and submitted to VPG Histology for examination. This revealed epidermal hyperplasia and prominent hyperkeratosis, areas of superficial epidermal necrosis and a mild inflammatory infiltrate within the epidermis and dermis. Faint outlines of structures suspected to…